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KMID : 0357919750090020131
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Korean Journal of Pathology
1975 Volume.9 No. 2 p.131 ~ p.135
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The Changes of Endothelian Cells in Rat Lung Alveoli Induceed by Carbon Monoxide Poisoning
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Abstract
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The blood capillaries of alveolar wall were the route of gas exchange, so that some
morphologic and functional changes were suspected in these capillaries in case of altered
gas exchange states, such as carbon monoxide poisoning. This study was carried out to
investigate the morphologic alteration in these capillaries. Rabbits were forced to inhalate
0.2％ CO gas for 2 hours (3 animals) and 4 hours (3 animals) and 0.1％ CO gas for 2
hours daily for 5 days respectively. The lungs were extracted out and observed by the
electron microscope.
Results were summarized as follow:
Pinocytotic vesicles were increased in number with occasional large vacuole formation.
Also noted were increase of lysosome, swelling of mitochondria with loss of crests,
dilatation of interendothelial gap and irregularity of plasma membrane. No significant
change was noted in the nuclei.
The results suggested that CO poisoning induced increased permeability with
degenerative changes of the endothelial cells, although these cells could easily contact to
oxygen of alveolarlumen.
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